| 1860 – House of Refuge: 100 beds are made available in the first Toronto shelter for the helpless and homeless. |
| 1872 – Smallpox Hospital: Converted to help contain the 1869 smallpox epidemic, the first in a series of outbreaks that lasted 30 years. |
| 1891 – Isolation Hospital: Renowned for its treatment of infectious diseases, including diphtheria, scarlet fever, tuberculosis, measles and polio. |
 | 1894 – School of Nursing: The Isolation Hospital established a training school to meet the great demand for specialized nursing skills in the treatment of infectious diseases. The school merged with the University of Toronto in 1918. |
 | 1893 – Diphtheria Vaccine: Led the way in using the vaccine as a means of preventing diphtheria in Ontario. |
 | 1902 – Medical Training: The Isolation Hospital became the recognized centre for educating medical students in the treatment of communicable diseases. |
 | 1902 – Swiss Cottage Hospital: The remaining patients of the Smallpox Hospital were moved to this new building which would accommodate all the smallpox cases in Toronto until 1927. The Swiss Cottage Hospital was demolished in 1930. |
 | 1927 – The Hastings Building: Built to address the most pressing health care issue of the day - measles. The Hastings Building is named after Dr. Charles Hastings, Chief Medical Officer of Health for the City of Toronto from 1910 to 1929, who was known worldwide as a visionary in the field of public health. |
 | 1930s – No Patient Turned Away: Even during the depression years, the fees for patients who were unable to pay were subsidized by the City of Toronto through the Isolation Hospital. |
 | 1945 – Regional Centre for Polio: Treated adults with respiratory polio from all over Ontario. The last iron lung was sent to Sarajevo in the 1980s. |
 | 1963 – The Riverdale Hospital: Opened with 800 beds to meet the growing need to support people with long-term illnesses in Toronto. |
 | 1972 – Stroke Recovery Unit: Introduced to rehabilitate patients, minimizing the effects of disability caused by stroke. |
 | 1975 – Oncology Palliative Care Unit: Opened with 10 beds and grew to a 40-bed unit within a year. |
| 1990 - Dialysis Unit: Opened for complex patients with kidney disease requiring complex medical care. |
 | 1990s – On-site Training and Education: Began on-site training of personal service providers through George Brown College. Provided on-site nursing degree programs through Ryerson University. |
 | 1995 – HIV/AIDS: Opened the first and only complex continuing care program for HIV/AIDS patients in Ontario. |
 | 2002 – Complex Chronic Disease: Rebranded as Bridgepoint Health, with a vision to transform programs and services to respond to the biggest health care challenge of the 21st century. |
 | 2005 – New Hospital Plans Approved: The Ontario Government endorses plans for a new state-of-the-art hospital for complex care and complex rehabilitation. |
 | 2006 – Academic Affiliation: Bridgepoint is designated a University of Toronto affiliated community teaching hospital, strengthening our education and research mandate. |
 | 2008 – Bridgepoint Family Health Team: Launched to extend our reach to individuals with, or at risk of developing, complex chronic disease by providing proactive primary care services in the community. |
 | 2008 – Leadership Award: Received the inaugural Institute of Public Administration of Canada (IPAC)/Deloitte Gold Award for Leadership in the Public Sector. |
 | 2009 – Professional Care Delivery Model: Implemented to ensure our professional staff are able to use their skills and training to the fullest extent possible, and to support our ability to meet the increasingly complex needs of our patients, now and in the future. |
 | 2009 – Expanded Research Focus: Launched the Bridgepoint Collaboratory for Research and Innovation. With the University of Toronto, establish the first Canadian Chair in Complex Chronic Disease Research. |
 | 2009 – Expansion in Clinical Teaching: Interprofessional Education Program welcomes more than 500 students from over a dozen disciplines – a number that will grow year-over-year. |